Tag Archives: 莆田桑拿

Sperm tested as possible candidate for delivering cancer medications in female patients

first_img © 2017 Phys.org In recent years, medical researchers have been focusing on developing carrier systems for delivery of chemicals to targets inside the body to treat ailments such as cancer, but thus far, it has been slow going due to a variety of issues such as the body responding in unhelpful ways or targets such as tumors putting up a tough front. In this new effort, the researchers looked into the idea of using a natural carrier to deliver helpful drugs to specified targets—sperm cells delivering drugs guided to tumors and other problem sites in the female reproductive tract.While it is known that sperm cells will swim around in the vagina searching for an egg to fertilize, and in some cases, have been known to swim up and fertilize eggs still in the fallopian tube, the randomness of their behavior was deemed too untenable for drug delivery—the team wanted to be able to steer individual sperm cells. To accomplish that feat, they coaxed sperm cells to swim into a very tiny helmet coated with iron that would adhere to its head. The sperm could then be steered using an external magnet. The helmet was designed with a quick-release mechanism that allowed it to dislodge from the sperm when it ran head first into something, such as a tumor cell, allowing the sperm cell to penetrate the tumor cell the same way it would an egg, delivering the drug. The researchers also found that they could cause a sperm cell to absorb a cancer drug simply by soaking it in a solution containing the drug.The researchers tested their idea using bull sperm on a tiny track in their lab. They report that they were able to successfully move the sperm cell to a desired location, HeLa cells and HeLa spheroids—stand-ins for tumor cells. They report also that the helmet caused the sperm to swim 43 percent more slowly than normal. Though the test results proved impressive, there are many hurdles to overcome before such a technique could actually be used in humans—first and foremost, preventing accidental pregnancies. There is also the issue of what happens to the abandoned helmets (thousands would be left behind) and whether a sperm cell could be steered around inside the human body. And then there is the problem of obtaining the sperm. Schematic depicting tumor targeted drug delivery by a sperm-hybrid micromotor under magnetic guidance with mechanical sperm release trigger. Credit: arXiv:1703.08510 [physics.med-ph] This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Sperm tested as possible candidate for delivering cancer medications in female patients (2017, April 14) retrieved 18 August 2019 from https://phys.org/news/2017-04-sperm-candidate-cancer-medications-female.html (a) Schematic illustration of the sperm-hybrid micromotor and the sperm release process. Black arrows represent the reactive force on the arms upon hitting an obstacle. (b) Top view of the tetrapod microstructure with schematic sperm head (c) SEM images of an array of printed tetrapod microstructures. (d) Simulation results demonstrating the deformation of one single arm. Yellow arrows represent the applied forces. (i) Applied force is 128 pN from a motile, non-hyperactivated sperm. (ii) Applied force is 450pN from a hyperactivated sperm. Credit: arXiv:1703.08510 [physics.med-ph] More information: Sperm-hybrid micromotor for drug delivery in the female reproductive tract, arXiv:1703.08510 [physics.med-ph] arxiv.org/abs/1703.08510AbstractA sperm-driven micromotor is presented as cargo-delivery system for the treatment of gynecological cancers. This particular hybrid micromotor is appealing to treat diseases in the female reproductive tract, the physiological environment that sperm cells are naturally adapted to swim in. Here, the single sperm cell serves as an active drug carrier and as driving force, taking advantage of its swimming capability, while a laser-printed microstructure coated with a nanometric layer of iron is used to guide and release the sperm in the desired area by an external magnet and structurally imposed mechanical actuation, respectively. The printed tubular microstructure features four arms which release the drug-loaded sperm cell in situ when they bend upon pushing against a tumor spheroid, resulting in the drug delivery, which occurs when the sperm squeezes through the cancer cells and fuses with cell membrane. Sperms also offer higher drug encapsulation capability and carrying stability compared to other nano and microcarriers, minimizing toxic effects and unwanted drug accumulation. Moreover, sperms neither express pathogenic proteins nor proliferate to form undesirable colonies, unlike other cells or microorganisms do, making this bio-hybrid system a unique and biocompatible cargo delivery platform for various biomedical applications, especially in gynecological healthcare. Journal information: arXiv Explore further (Phys.org)—A team of researchers with the Institute for Integrative Nanosciences in Germany has tested the possibility of using sperm cells to deliver drugs to cancerous tumors in female patients. In their paper uploaded to the preprint server arXiv, the group describes how such a technique might work, their initial test results and what they learned from their experiments. Sperm with specific ‘looks’ are selected to fertilise bird eggs, say scientistslast_img read more

7 Seater Car and MPV Hire in Orlando

first_img Related7+ Seater Car and MPV HireWhy hire a 7, 8 or 9 seater car? Large MPVs and 7+ seater cars are a great option for family or group holidays if you’re planning to do a lot of traveling. The additional seating and spacious cabins ensure that all your passengers have plenty of space with room…7+ Seater Car and MPV Hire in MalagaPopular Car Hire Locations Near Malaga 7+ Seater Car Hire from Malaga Airport 7+ Seater Car Hire from Gibraltar Airport How to search for 7+ seater cars to hire in Malaga on Skyscanner Using the search box above, or on our Malaga car hire page, select your pick-up location as…7+ Seater Car and MPV Hire in DublinPopular Car Hire Locations Near Dublin 7+ Seater Car Hire from Dublin Airport How to search for 7+ seater cars to hire in Dublin on Skyscanner Using the search box above, or on our Dublin car hire page, select your pick-up location as well as the pick-up and drop-off dates… At a certain size, minivans start to look less like a car/van hybrid and more like a small bus. Indeed, large minivans are essentially commercial vans you’d typically see being driven by tradesmen or being used to transport goods, but in this case outfitted with multiple rows of seats to accommodate up to 9 passengers and all their luggage and usually much more luxuriously equipped. Often used as executive shuttle busses by hotels, these can also be hired from rental companies for personal use if you are travelling with a large group or just have a lot of luggage and equipment to transport. Examples of vehicles in this class include: MPV (aka Minivan, Multi-purpose vehicle, people carrier) Popular Car Hire Locations Near Orlando SUVs are a common site on roads all over the world now – large vehicles usually with ample ground clearance giving them an off-road look (although they are not always 4wd and not always suitable for offroading!) providing practical space, high driving position and plenty of seating. The larger vehicles in this category can comfortably seat 7 with reasonable luggage space left over. 7 seaters in this category include: Mercedes E-Class EstatePeugeot 308 SWAudi A6 Avant 7+ Seater Car Hire from Orlando International Airport Volvo XC90Peugeot 5008Nissan X-TrailKia SorentoLand Rover Discovery 7+ Seater Car Hire from Orlando Sanford Airport There are several different types of 7+ seater cars and, depending on where you are hiring from, one or more of the following types may be available: These are probably the most common type of 7+ seater family car available today. Essentially a van shaped car with three rows of seats and typically with sliding rear doors providing easy access to the two back rows of seats. Examples of cars in this class include: Using the search box above, or on our Orlando car hire page, select your pick-up location as well as the pick-up and drop-off dates and times then hit Search ->When the results have loaded, select 7+ from the Passengers filters in the Filter menu.Choose a preferred pickup location from the map or the list to see the selection of 7+ seater cars available to hire from that location.When you find one that suits your needs, click on the Select button to be shown price options from different suppliers and see more detail about the rental options.When you find one you would like to book, click on Select next to that option to be taken to the site where you can reserve the vehicle. Large estate cars with 7+ seats are less common to find these days, having mostly been replaced by MPVs and SUVs, but some are still around and may be available depending on where you are renting your car from. Estate cars are often extended versions of hatchbacks or saloons, creating additional boot space and, in some cases also allowing an extra row of seats, whilst still being a low to the ground car. These are often known as 5+2 seat cars as they usually don’t have a proper back row of seats and instead just have 2 extra seats which fold out from the floor of the boot. This of course may mean sacrificing luggage space if you want to use one of these to carry 7 people. Examples of cars in the class include: How to search for 7+ seater cars to hire in Orlando on Skyscanner SEAT AlhambraVolkswagen SharanFord GalaxyChrysler Grand VoyagerMercedes-Benz V-Class SUVs (aka 4x4s, Sports Utility Vehicles) Pick-up LocationPick-up DateTime00:0000:3001:0001:3002:0002:3003:0003:3004:0004:3005:0005:3006:0006:3007:0007:3008:0008:3009:0009:3010:0010:3011:0011:3012:0012:3013:0013:3014:0014:3015:0015:3016:0016:3017:0017:3018:0018:3019:0019:3020:0020:3021:0021:3022:0022:3023:0023:30Drop-off DateTime00:0000:3001:0001:3002:0002:3003:0003:3004:0004:3005:0005:3006:0006:3007:0007:3008:0008:3009:0009:3010:0010:3011:0011:3012:0012:3013:0013:3014:0014:3015:0015:3016:0016:3017:0017:3018:0018:3019:0019:3020:0020:3021:0021:3022:0022:3023:0023:30Return car to a different locationDriver aged between 25 – 75Search Estate Cars Volkswagon Transporter ShuttleMercedes Vito TravelinerFord Transit 9 SeaterPeugeot Traveller Large Minivan Types of 7+ Seater Vehicles to Hire in Orlandolast_img read more