Reviewed by James Ives, M.Psych. (Editor)Oct 10 2018Spurred by the rapidly expanding use of in-home tests for “omic” – genomic and microbiomic – data for humans, pets, and even homes themselves, university researchers have begun tackling the difficult challenge of making the results interactive and understandable to non-experts.While misinterpreting a pet’s lineage or the tracks of a cockroach across a kitchen countertop may or may not carry large financial consequences, scientific literature brims with examples of incorrect or misinterpreted omic home-test results that prompted expensive and unnecessary follow-up medical tests. Already, more than 5 million reports of genetic and microbiome (the bacteria, viruses, and fungi that live in and on our bodies) have been delivered as a result of such direct-to-consumer tests, and in some cases the emotional toll can be as consequential as the financial.Supported by a new National Science Foundation (NSF) grant, NYU Tandon School of Engineering Associate Professor Oded Nov, an expert in human-computer interaction, leads the research project with Associate Professor Orit Shaer of Wellesley College. The team is working with the Open Humans Foundation platform to fashion user studies en route to first-of-their-kind tools that he hopes industry will widely adopt.Related StoriesGrowth problems in preterm infants associated with altered gut bacteriaNew strategy may strengthen gut-brain communicationWarning issued by FDA after patient dies following fecal transplantThe team is developing mobile apps to allow users to share results and curated medical news with others within their families or a community interested in the same disease, for example. In the process, the researchers plan to design and test best practices for communicating and interacting with complex genomic and biome data.In addition, the researchers will build an UbiqOmic space to test volunteers’ understanding of data presentation and interaction tools. They will also conduct a longitudinal study in three households, whose members will self-monitor for allergens or undesired food ingredients – and perhaps discover how changing these ingredients affects their own microbiome and those of other people in the household. As part of NYU Tandon’s ITEST summer program supported by the NSF, Nov will engage New York City middle and high school students and teachers in the project.Nov, a member of the NYU Tandon faculty in the Department of Technology Management and Innovation, has long focused on human-computer interaction and social computing. He holds degrees from Tel Aviv University, the London School of Economics, and Cambridge University. His many honors include a National Science Foundation CAREER Award, as well as grants from Google, the MacArthur Foundation, and the National Academies Keck Futures Initiative.The NSF Division of Information and Intelligent Systems granted $500,000 for the research, which NYU and Wellesley College share equally.Source: http://www.poly.edu/news/new-apps-take-confusion-out-genome-and-microbiome-home-tests
People with diabetes have a high risk of developing complications due to extended periods of elevated glucose levels. These complications could include nerve damage, kidney disease, and eye disease. But a rare subset of people who have had insulin-dependent diabetes for more than 50 years have avoided such complications. For 15 years, Joslin researchers have tracked these individuals as part of the Medalist Study. They noted that 35 percent of patients avoided retinopathy, even when they had elevated glucose levels.Dr. King and his team deduced that these patients must have something endogenous-;or created by their own body that are neutralizing the toxic effects of high glucose levels. This new study aimed to build on this observation, to determine which molecules could be responsible for the protection of the eye.They took biosamples from the eyes of Medalists -; both from living patients during surgery and from people who had donated their eyes postmortem. They then characterized the many proteins that were present, to determine if any proteins were elevated more in the protected eyes than in eyes of people who developed retinopathy.They recognized that RBP3, a protein only made in the retina/eye, was elevated. To determine if this was indeed the protective factor they were looking for, they constructed experiments to compare normal versus increased expression of RBP3 in mouse models. Mice with increased RBP3 expression were protected from developing diabetic retinopathy.Next, the researchers injected pure RBP3 into the vitreous of the eyes of mice in the early stages of retinopathy. The infusion of RBP3 reversed the damages done by early eye disease. They also discovered that diabetes seems to reduce the expression of RBP3 in eye in many subjects, which could explain why its protective effects are limited to only some patients.Related StoriesEye research charity funds development of ‘organ-on-a-chip’ to fight glaucomaStudy reveals a revolutionary way to treat eye injuries, prevent blindness’Eye-in-a-dish’ model helps scientists to uncover ‘surprising’ AMD gene variant”If we could find out what’s causing the decrease of RBP3 in the retina in the first place, we could design some kind of treatment to maintain its production, allowing all diabetic patients to have an endogenous protection against eye disease,” says Dr. King.RBP3 is found in all eyes. Normally, it is used to regenerate a certain type of vitamin A in the eye that powers sight-giving rods and cones. But when the eye is exposed to high glucose levels, RBP3 changes its role.”It appears to decrease the toxic effects of high glucose levels that exist in diabetes by reducing the entering of glucose into several important retinal cells by inhibiting the actions of a glucose transporter, GLUT-1.” says Dr. King.Understanding these mechanisms may allow researchers to develop a targeted treatment to fight early-stage retinopathy. Currently, severe retinopathy can be addressed by the Joslin-developed treatments of either laser photocoagulation or VEGF inhibitor injections.”We are interested in how we can treat diabetic eye disease at its earliest stages before it gets to the severe forms,” says Dr. King.One surprising finding from this study showed that RBP3, while it mainly resides in the eye, can also be detected to some degree in the bloodstream. Dr. King and team have planned follow-up studies to determine if RBP3 levels in the bloodstream correlate with severity of diabetic retinopathy. If they do, this circulating RBP3 could become a biomarker that doctors can use to screen for retinopathy during regular lab tests.”That could be a very important screening tool for family or internal medicine doctors who are not experts at examining the eye,” says Dr. King. “Right now, all people with diabetes have to be sent to ophthalmologists to really give us a sense of the status of their eyes with regard to diabetes. So, if this could be a general screen, we may be able to catch more cases of retinopathy earlier in the disease course.”Joslin and its Beetham Eye Institute have a strong history of developing treatments for retinopathy. This discovery brings them a step closer to prevention of the devastating complication.”This has the potential to become equally as important as our previous discovery of VEGF as critical for diabetic proliferative disease or severe diabetic eye disease,” King says. Source:Joslin Diabetes Center Reviewed by James Ives, M.Psych. (Editor)Jul 4 2019Researchers at Joslin Diabetes Center have shown that a protein found in the eye can protect against and potentially treat diabetic eye disease. At high enough levels, Retinol Binding Protein 3 (or RBP3) prevents the development of diabetic retinopathy. If introduced early enough in the development of the disease, RBP3 was shown to reverse the effects of the complication in rodent models of diabetes. These results are reported today in Science Translational Medicine. The level of RBP3 in the eye’s vitreous and retina are higher in people who don’t progress to diabetic eye disease than in those who do. Building on that observation, we saw that if you overexpress RBP3 by molecular methods [in animal models], you can prevent the onset of diabetic eye disease. And when we injected RBP3 itself into the vitreous of diabetic rats, we reversed some of the early changes of diabetic eye disease.”George King, Chief Scientific Officer at Joslin Diabetes Center and senior author on the paper
Citation: Researcher sees potential in generating energy from vibrations (2019, March 8) retrieved 17 July 2019 from https://phys.org/news/2019-03-potential-energy-vibrations.html As an aerospace engineer who specializes in designing structures to avoid destructive vibrations, it was only natural for Levin to approach the quest for sustainable energy by applying what he knows about flutter and limit cycle oscillations, or LCO. Because of its potential to cause structural failure, flutter is nearly always engineered out of structures. “Usually flutter is not desirable,” said Levin. “But sometimes violent flutter can turn into moderate LCO, which will cause no failure, and this can be useful.” Levin wanted to explore the potential of harnessing the energy generated by flutter, and he took a six-month detour from his dissertation work, with the support of his advisor.Levin set up an experiment in the aeroelasticity lab’s wind tunnel, using a thin aluminum plate and piezoelectric elements, which generate voltage in response to mechanical stressors like flutter. He found that by increasing the vibrations’ frequency and amplitude, creating more curvature in the vibrational motion, using efficient piezoelectric elements and reducing air speed, he could squeeze the most power from the motion of the plate—sometimes increasing efficiency by more than 200 percent. Are large-scale flutter farms in our future? Probably not, said Levin. “My vision for this is, maybe you go on a long hike, on a cloudy day. You don’t have any solar power to charge your phone. But you do have a folded generator in your bag that you can take out, let it catch the breeze as you hike, and it can charge your phone. You can go even further and combine solar and wind. It’s scalable and useful. And,” he added jokingly, “it doesn’t involve scary mathematics. We’re using something that is so simple and so basic—at least for an aerospace engineer.”Levin will present his project, titled “Improving Piezoelectric Energy Harvesting from an Aeroelastic System,” at the International Forum on Aeroelasticity and Structural Dynamics in Savannah, Georgia in June of 2019. Provided by Duke University This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Credit: Duke University “Everyone is trying to get free energy—from the wind, from the waves, from the sun,” said Dani Levin, a Duke MEMS Ph.D. student in the lab of Professor Earl Dowell. Scientists harvest energy from beam’s self-induced, self-sustaining vibrations in airflow Explore further
Analysis of the flight recorders of the crashed Ethiopian Airlines plane has begun, the airline said Friday, and The New York Times reported that the pilot requested permission “in a panicky voice” to return to the airport shortly after takeoff as the plane dipped up and down sharply and appeared to gain startling speed. © 2019 The Associated Press. All rights reserved. Investigators looking into the Indonesian crash are examining whether the software automatically pushed the plane’s nose down repeatedly, and whether the Lion Air pilots knew how to solve that problem. Ethiopian Airlines says its pilots received special training on the software.At the crash site in Hejere, about 50 kilometers (31 miles) from Addis Ababa, searchers continued to pick through the debris. Blue plastic sheeting covered the wreckage of the plane. Students from an elementary school walked an hour and a half to the site to pay respects.Anxious family members began giving DNA samples and waited for news on the identification of remains. Members of Israel’s ZAKA emergency response team were granted access to the site for forensic work.Canada’s ambassador to Ethiopia, Antione Chevrier, told The Associated Press that discussions on repatriating remains would begin once the identification process begins to yield results. “The next steps will take some time,” he said. Canada lost 18 people.”We are not told what they have found so far,” Ethiopian citizen Faysal Hussein, whose cousin was killed, told the AP. “We are sitting here like forever. We were taken to the crash site on Wednesday but not allowed to get a closer look.”One relative collected soil in a plastic bag, perhaps for lack of anything else .A Kenyan citizen, Pauline Gathu, lost a brother. Thirty-two Kenyans were killed.”We were expecting that we will have our body well-kept but we are amazed to hear that there is nothing, totally nothing,” she said. “And people are waiting for us to give them reports of what we have found but we don’t have words, we don’t know what to do.” Ethiopian relatives of crash victims mourn and grieve at the scene where the Ethiopian Airlines Boeing 737 Max 8 crashed shortly after takeoff on Sunday killing all 157 on board, near Bishoftu, south-east of Addis Ababa, in Ethiopia Thursday, March 14, 2019. About 200 family members of people who died on the crashed jet stormed out of a briefing with Ethiopian Airlines officials in Addis Ababa on Thursday, complaining that the airline has not given them adequate information. (AP Photo/Mulugeta Ayene) Ethiopian Airlines crash: What is the MCAS system on the Boeing 737 Max 8? Citation: Ethiopian Airlines says analysis of flight recorders begins (2019, March 15) retrieved 17 July 2019 from https://phys.org/news/2019-03-ethiopian-airlines-analysis-flight.html The Max is the latest upgrade to the Boeing 737s. Because its engines are larger and heavier, they are placed higher and farther forward on the wings. That created concern that the plane might be slightly more prone to an aerodynamic stall if not flown properly, so Boeing developed software to prevent that. The report cited “a person who reviewed air traffic communications” from Sunday’s flight saying controllers noticed the plane was moving up and down by hundreds of feet.An airline spokesman has said the pilot was given permission to return. But the plane crashed minutes later outside Addis Ababa, killing all 157 on board.French authorities now have the plane’s flight data and voice recorders for analysis. They have said it was unclear whether data could be retrieved. The data recorder appeared to show damage. Ethiopian Airlines said an Ethiopian delegation led by its chief accident investigator had arrived in Paris.In Ethiopia, officials started taking DNA samples from victims’ family members to assist in identifying remains. The dead came from 35 countries.Countries including the United States have grounded the Boeing 737 Max 8 as the U.S.-based company faces the challenge of proving the jets are safe to fly amid suspicions that faulty software might have contributed to two crashes that killed 346 people in less than six months.The decision to send the flight recorders to France was seen as a rebuke to the United States, which held out longer than most other countries in grounding the jets. The U.S. National Transportation Safety Board sent three investigators to help French authorities.The U.S. Federal Aviation Administration said regulators had new data from the satellite-based tracking that showed the movements of Ethiopian Airlines Flight 302 were similar to those of Lion Air Flight 610. That flight crashed into the Java Sea off Indonesia in October, killing 189 people.The data show both planes flew with erratic altitude changes that could indicate the pilots struggled to control the aircraft. Both crews tried to return to the airport.Boeing said it supports the grounding of its planes as a precautionary step, while reiterating its “full confidence” in the safety of the 737 Max. Engineers are making changes to the system designed to prevent an aerodynamic stall if sensors detect that the jet’s nose is pointed too high and its speed is too slow.Boeing also announced it had paused delivery of the Max, although the company planned to continue building the jets. This photo provided by by the French air accident investigation authority BEA on Thursday, March 14, 2019, shows one of the black box flight recorder from the crashed Ethiopian Airlines jet, in le Bourget, north of Paris. The French air accident investigation agency has released a photo of the data recorder from the crashed Ethiopian Airlines jet. The agency, known by its French acronym BEA, received the flight’s data recorder and voice recorder Thursday. (BEA via AP) Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoVikings: Free Online GamePlay this for 1 minute and see why everyone is addictedVikings: Free Online GameUndoAncestryThe Story Behind Your Last Name Will Surprise YouAncestryUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoClassmatesSearch For Any High School Yearbook, It’s Free.ClassmatesUndoGundry MD SupplementsTop Cardiologist: This One Thing Will Properly Flush Out Your BowelsGundry MD SupplementsUndo 13 Ways to Hunt Intelligent Aliens If we discover a signal from extraterrestrial intelligence, would you: — Not care much about it? — Just follow the news, comment? — Interact on social media about this topic? And this one: Some people think we should send messages into space even if we don’t receive a message first. What is your opinion? — This is a bad idea. We should ban people from sending messages. — There should be rules or laws about who can send messages and what they can say. — Anybody who wants to send a message into space should be allowed to do so. So, what are the odds we’d really need answers to these questions? To date, a lot of effort and money have gone into listening for alien signals. For instance, Breakthrough Listen’s team at the University of California, Berkeley’s SETI Research Center released 1 million gigabytes of data related to such a quest. The scientists had looked for anomalous pings in both radio and optical wavelengths emitted by 1,327 star systems. The result? None of those signals could be traced to anything other than human sources. Just this month, the Mutual UFO Network (MUFON) celebrated 50 years of looking for and studying UFO phenomenon. The nonprofit relies on volunteers to help find and identify these objects. Though the members insist that “we are not alone,” they have yet to spot conclusive evidence to support that claim. Even the U.S. government has suggested it’s serious about investigating bizarre craft of unknown origin. In 2017, the Pentagon confirmed that a secret “UFO” office — called the Advanced Aerospace Threat Identification Program — had spent $22 million over five years to study such baffling aeronautical reports. And even though funding ended in 2012, the program apparently remained alive. More recently, declassified videos have shown U.S. Navy pilots talking about seeing UFOs that demonstrated unexplainable properties. “Despite the fact that we [have] never detected a signal from extraterrestrial intelligence, this does not mean that it is never going to happen. What if it does?” Martin Dominik, an astrophysicist at the University of St. Andrews in the United Kingdom, told Live Science in an email. “The SETI community are currently rethinking this issue in the wake of the spread of social media and fake news. If there are consequences for the wider public, the decision about where to go becomes a political one rather than a scientific one,” said Dominik, who is also a UKSRN member. What have researchers learned so far from the survey responses? “I do not want to release any data at this moment, because it would bias the views of those who are still to respond,” Dominik said. Check out the survey and let the SETI group know what you’d do upon contact with extraterrestrial intelligence. 80 Years Ago, ‘News’ of an Alien Invasion Terrified Radio AudiencesEighty years ago today (Oct. 30), radio audiences were stunned by a purported news broadcast describing an “alien invasion” in New Jersey.Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65848-alien-contact-seti-survey.html?jwsource=cl已复制直播00:0002:1202:12Your Recommended Playlist01:33Better Bug Sprays?01:08Why Do French Fries Taste So Bad When They’re Cold?04:24Sperm Whale Befriends Underwater Robot00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭 UFO Watch: 8 Times the Government Looked for Flying Saucers 9 Strange, Scientific Excuses for Why Humans Haven’t Found Aliens Yet The quest to identify UFOs and even find intelligent life on other worlds has been heating up for decades … to no avail. But there are still plenty of spots and wavelengths where aliens could be hiding. So, what would humans do if we found concrete evidence that we are not alone in the universe? Turns out, there’s no real plan for how humanity would respond, let alone how we would deal with such a monumental discovery. The U.K. SETI Research Network (UKSRN) wants to change that by asking Earthlings their views on the search for aliens and how they’d react to a discovery. The network announced the survey, which it said is the largest such survey to date, yesterday (July 1) during the Royal Society’s Summer Science Exhibition, according to The Guardian. [Greetings, Earthlings! 8 Ways Aliens Could Contact Us] The online survey includes questions such as: AdvertisementFamous People Who Believe in AliensFrom pop stars to Hollywood actors to politicians, here are 13 famous people who believe in aliens.Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65848-alien-contact-seti-survey.html?jwsource=cl已复制直播00:0001:2601:26Your Recommended Playlist01:33Better Bug Sprays?01:08Why Do French Fries Taste So Bad When They’re Cold?04:24Sperm Whale Befriends Underwater Robot00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭