Eden Hazard misses only his second league game of the season after injury ruled him out of Chelsea’s trip to Stoke.The Belgian is replaced in the Blues’ starting line-up by Pedro, the only change to the side that beat Manchester United in Monday’s FA Cup quarter-final.Victor Moses is in the side despite a calf problem sustained against United, while Nemanja Matic continues in midfield ahead of Cesc Fabregas.John Terry is not included in the squad, with Nathan Ake named on the bench instead.Stoke’s former Chelsea defender Glen Johnson is out with a shoulder problem but Marko Arnautovic returns to the side after missing out in midweek because of illness.Xherdan Shaqiri, though, misses his seventh match in a row.Stoke: Grant; Bardsley, Shawcross, Martins Indi, Pieters; Ramadan, Cameron, Allen, Arnautovic; Walters, Berahino.Subs: Given; Muniesa, Whelan, Afellay, Adam, Diouf, Crouch.Chelsea: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Matic, Alonso; Willian, Costa, Pedro.Subs: Begovic, Zouma, Ake, Chalobah, Loftus-Cheek, Fabregas, Batshuayi. Ads by Revcontent Trending Articles Urologists: Men, Forget the Blue Pill! This “Destroys” ED x ‘Genius Pill’ Used By Rich Americans Now Available In Netherlands! x What She Did to Lose Weight Stuns Doctors: Do This Daily Before Bed! x Men, You Don’t Need the Blue Pill if You Do This x One Cup of This (Before Bed) Burns Belly Fat Like Crazy! x Drink This Before Bed, Watch Your Body Fat Melt Like Crazy x Follow West London Sport on TwitterFind us on Facebook
A huge cistern near the Temple Mount has been found that was part of Solomon’s Temple complex.While excavating a cardo (street) that passed from the City of David to the Temple Mount, a team broke into a huge cistern. Dating from the time of Solomon based on inscriptions and the type of plaster used, the cistern helps explain where the priests and worshipers obtained the large quantity of water that were needed for the Temple. The discovery is reported fully at Israel Hayom. A short YouTube video shows explorers walking inside the huge cavernous water reservoir. Live Science also reported the find, as did Bible Places Blog.The discovery solves a water logistics problem. Historians had thought that Jerusalem’s only water supply was the Gihon Spring, some 800 meters away from the Temple. But that would have required an implausible number of donkey trips to haul the water. By catching rainfall from the Tyropoean Valley adjacent to the Temple, this cistern could have stored a vast water supply for the priests to use in the sacrificial ceremonies and for the large crowds coming to the Temple for holy days. It could also have protected the city during times of siege.One of the discoverers was ecstatic about the find. “There is nothing like this in Jerusalem. This is the first time that we can date a reservoir in Jerusalem, and two small cisterns beside it, to the First Temple era. We have never found anything like this in all the digs in Jerusalem, since the 19th century.”Archaeology is an intelligent-design science. Researchers look for signs of intelligence: artifacts, inscriptions, or other material that bear the hallmarks of intention. Intelligent beings are capable of organizing natural materials for purposeful uses. We see it in archaeology; we see similar marks of purpose in living cells. In addition, archaeologists are keen observers. They don’t just model things in computers; they get out and dig (although there is a growing convergence of computer technology with old-fashioned shoveling techniques).This particular find shows, also, that contrary to “minimalist” interpretations of Biblical history, the people of Solomon’s time were highly intelligent, able to dig deep into the rock to store the water needed for the Temple. Far from being simple tribal chieftans over nomadic clans, David and Solomon were city planners and builders par excellence. Most likely the plans for this cistern and the entire Temple Mount complex were developed long before actual construction began. King David was laying up materials and building contracts with neighboring kingdoms before his death (I Chronicles 22). The cistern is another testament to their skill, and to the historical accuracy of the Biblical record. (Visited 19 times, 1 visits today)FacebookTwitterPinterestSave分享0
By Ntombi Ntanzi“You are the new generation that’s going to change the way of doing things”, these are the words echoed by Brand South Africa’s General Manager of Marketing, Ms Sithembile Ntombela to the learners of Dr WF Nkomo Secondary School in Atteridgeville, during a Play Your Part school activation on Wednesday 16th May 2018.Brand South Africa through the Play Your Part programme continues to engage with the youth, specifically high school learners in a nationwide campaign.“This nationwide Play Your Part campaign is aimed at learners to ensure they are continuously introduced and made aware to be active citizenship from a young age, in order to grow communities of leaders, growing our youth that will carry the legacy and vision of South Africa in the future”; adds Ms Ntombela.The campaign kicked off in collaboration with famous comedians Goliath and Goliath, who are also Play Your Part ambassadors. They coached, entertained and educated through comedy by giving a masterclass to the grade 11 and 12 learners on realising your dreams.“Play your part is about you taking ownership. Start changing the world with little parts of the world that you are affected by”; said comedian Jason GoliathSpeaking to a Grade 12 learner – Leanna Mathatu at the school on what she took out from the Play Your part activation she said: “trust yourself, follow your dreams and take charge.”Book Ibhoni founder and a Play Your Part ambassador, Mpumi Mtintso spoke on the promotion of innovation and entrepreneurship under the theme “Play Your Part, turn your ideas into currency”.He expressed that every path that the young people take on for their future, career and passion needs to speak to the county’s vision articulated in the National Development Plan(NDP). “Make sure you solve issues of poverty, inequality and the high rate of unemployment”, emphasized Mtintso.Some learners took to social media to share their gratitude;Lemonade ? @MaleboMolapo1 May 16@DonovanGoliath @JasonGoliath @nickgoliath ..Thank you so much for coming to our school, I really enjoyed. I laughed so hardOn the 30th May 2018, the Play Your school activation will be heading to a school in Mpumalanga follow the conversation on @PlayYourPartSA and @Goliath_Goliath remember to #PlayYourPart #GetInvolved
Toad for Cloud Databases is a version of Quest’s popular Toad tool specially designed for next-generation databases. So far it supports AWS SimpleDB; Microsoft Azure; Table services; Apache HBase; Microsoft SQL Azure; Apache Cassandra or any ODBC-enabled relational database. It can be downloaded here.Toad got its start as Tool for Oracle Databases (TOAD). Quest bought the tool in 1998 and has continued its development. Toad competes with open source projects such as TOra and SQLTools++.The existing flavors of Toad, such as Toad for MySQL, have long been popular with database professionals. Quest’s move into NoSQL demonstrates how much interest there is in the area. According to RedMonk’s Michael Coté, Toad for Cloud Databases already has over 2,000 users – not bad for a tool for managing relatively new and esoteric technologies. Coté writes that Hadoop is the most popular database among Toad for Cloud users.Quest is positioning itself as a trusted source for NoSQL tools and information. In addition to Toad for Cloud, Quest is running a wiki dedicated to NoSQL. The entry “Survey Distributed Databases” is an extensive overview of burgeoning field of NoSQL players. Quest staffers have been giving interviews on the subject of NoSQL and Hadoop as well. Tags:#cloud#Trends Why Tech Companies Need Simpler Terms of Servic… klint finley 8 Best WordPress Hosting Solutions on the Market Top Reasons to Go With Managed WordPress Hosting A Web Developer’s New Best Friend is the AI Wai… Related Posts
Slow and steady hope for near-extinct Bangladesh tortoises View comments Globe Business launches leading cloud-enabled and hardware-agnostic conferencing platform in PH Typhoon Kammuri accelerates, gains strength en route to PH Don’t miss out on the latest news and information. Read Next NEXT BLOCK ASIA 2.0 introduces GURUS AWARDS to recognize and reward industry influencers The fight over Wahoo has spanned decades in Cleveland.Every year, groups of Native Americans and their supporters have protested outside the stadium before the home opener in hopes of not only getting the team to abolish Chief Wahoo but to change the Indians’ nickname, which they feel is an offensive depiction of their race.Those dissenting voices have been met with fans devoted to preserving Chief Wahoo’s place in team history. The Indians’ resurgence in the mid-1990s helped spur a downtown renaissance in Cleveland.The NFL’s Washington Redskins have come under similar fire to change their logo and nickname but so far have resisted. Last year, a Supreme Court ruling in another case cleared the way for the Redskins to preserve the trademark on its logo. Kammuri turning to super typhoon less likely but possible — Pagasa 2 ‘newbie’ drug pushers fall in Lucena sting MOST READ LATEST STORIES FILE – In this June 19, 2017 file photo, members of the Cleveland Indians wear uniforms featuring mascot Chief Wahoo as they stand on the field for the national anthem before a baseball game against the Baltimore Orioles in Baltimore. The Cleveland Indians are taking the divisive Chief Wahoo logo off their jerseys and caps, starting in 2019. (AP Photo/Patrick Semansky, File)CLEVELAND — Divisive and hotly debated, the Chief Wahoo logo is being removed from the Cleveland Indians’ uniform next year.The polarizing mascot is coming off the team’s jersey sleeves and caps starting in the 2019 season, a move that will end Chief Wahoo’s presence on the field but may not completely silence those who deem it racist.ADVERTISEMENT “Nonetheless, the club ultimately agreed with my position that the logo is no longer appropriate for on-field use in Major League Baseball, and I appreciate Mr. Dolan’s acknowledgement that removing it from the on-field uniform by the start of the 2019 season is the right course.”Under growing pressure to eliminate Chief Wahoo, the club has been transitioning away from the logo in recent years. The Indians introduced a block “C″ insignia on some of their caps and have removed signs with the Wahoo logo in and around Progressive Field, the team’s downtown ballpark.National criticism and scrutiny about the Indians’ allegiance to Chief Wahoo grew in 2016, when the Indians made the World Series and Manfred expressed his desire to have the team eradicate the symbol. Earlier in that postseason, a lawsuit was filed while the club was playing in Toronto to have the logo and team name banned from appearing on Canadian TV. That court case was dismissed by a judge.The Indians’ bid to host the 2019 All-Star Game, which it was ultimately awarded, further heightened debate over Wahoo.“We have consistently maintained that we are cognizant and sensitive to both sides of the discussion,” Dolan said. “While we recognize many of our fans have a long-standing attachment to Chief Wahoo, I’m ultimately in agreement with Commissioner Manfred’s desire to remove the logo from our uniforms in 2019.”ADVERTISEMENT Abueva finally shows up at Gilas practice John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding Trending Articles PLAY LIST 00:50Trending Articles01:04Trump attends World Series baseball game in Washington DC00:50Trending Articles01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City Brace for potentially devastating typhoon approaching PH – NDRRMC The Associated Press was informed of the decision before an official announcement was planned for Monday by Major League Baseball.After lengthy discussions between team owner Paul Dolan and MLB Commissioner Rob Manfred, the Indians are taking the extraordinary step of shelving the big-toothed, smiling, red-faced caricature, which has been used in used in various expressions by the team since 1947.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSLillard, Anthony lead Blazers over ThunderSPORTSMalditas save PH from shutoutHowever, the American League team will continue to wear the Wahoo logo on its uniform sleeves and caps in 2018, and the club will still sell merchandise featuring the mascot in Northeast Ohio. The team must maintain a retail presence so that MLB and the Indians can keep ownership of the trademark.“Major League Baseball is committed to building a culture of diversity and inclusion throughout the game,” Manfred said in a statement. “Over the past year, we encouraged dialogue with the Indians organization about the club’s use of the Chief Wahoo logo. During our constructive conversations, Paul Dolan made clear that there are fans who have a longstanding attachment to the logo and its place in the history of the team.
LATEST STORIES MOST READ Robredo should’ve resigned as drug czar after lack of trust issue – Panelo Don’t miss out on the latest news and information. Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ View comments Trump signs bills in support of Hong Kong protesters Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Celebrity chef Gary Rhodes dies at 59 with wife by his side NATO’s aging eye in the sky to get a last overhaul Sports Related Videospowered by AdSparcRead Next San Beda cruises to 8th straight; Bolick ejected after scuffle Roger Pogoy. Photo from Fiba.comGilas Pilipinas is set to compete in the 2017 Fiba Asia Champions Cup which runs from Sept. 22-30 in Shenzen, China.National team coach Chot Reyes announced Gilas’ participation in the tournament Tuesday on his Twitter account.ADVERTISEMENT Lacson: SEA Games fund put in foundation like ‘Napoles case’ Hotel says PH coach apologized for ‘kikiam for breakfast’ claim “Breaking: Chooks-to-Go Pilipinas joins @FIBAAsiaCC. Games will be shown @TV5manila & @Sports5PH,” Reyes wrote.The tournament features some of Asia’s best club teams with China’s Xinjian Flying Tigers tipped to repeat as champions. The Flying Tigers will be led by naturalized Filipino Andray Blatche.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingGilas, which finished in seventh place in the Fiba Asia Cup last month, will use the competition as part of its buildup for the Fiba World Cup Qualifying in November. Celebrity chef Gary Rhodes dies at 59 with wife by his side
By Philem Dipak Singh New Delhi, Sep 13 (PTI) Fighting a dope taint, weightlifter Sanjita Chanu’s troubles mounted Thursday with her ‘B’ sample also returning positive but the defiant Commonwealth Games gold-medallist will fight her case before the international body’s hearing panel. Chanu has decided to present her case before the hearing panel of the International Weightlifting Federation (IWF) in Hungary. If Sanjita fails to prove her innocence before the IWF hearing panel, she faces a maximum punishment of four years, as stipulated for a first-time offender. “The B sample test was sent to Sanjita on September 11 and we will present our case before the IWF hearing panel in Budapest. We will highlight the mistakes committed by the IWF in this case,” Sanjita’s brother Bijen Singh told PTI. “It (the international body) has admitted its mistakes. We are confident of winning the case,” he added. Should her fight fail in the IWF, Sanjita is likely to knock at the doors of the Court of Arbitration for Sports (CAS) in Switzerland. “We will fight for justice till the end. We will do whatever is available to us. She has been wronged,” he added. In the letter which informed her about the ‘B’ sample result, the IWF had given time till September 18 to tell the world body whether she wishes to appear before a hearing panel. She was given the option to be present in person at a regular IWF hearing session, or at an extraordinary hearing, or through phone conference or skype.advertisement In reply, Sanjita wrote, “I would like to appear before the hearing panel through my representative (or myself) to prove my innocence.” Sanjita is now mulling whether to appear in person or send a lawyer. “Considering the cost involved for two persons (Sanjita and a lawyer) going to Hungary, we may send just a lawyer to represent her in the hearing in Budapest. But it is not yet finalised. We will take a call on it in the next few days,” Bijen said. The IWF, earlier in the year, admitted to committing an “administrative mistake” in giving the exact sample number of Sanjita in its report of her failed dope test. It had mentioned two different sample numbers in its communication of her dope flunk on May 15 and Sanjita had demanded an inquiry. The National Anti-Doping Agency said that the IWF’s admission will not have any impact on the actual doping issue. The admission from the IWF came after the issue reached the Prime Minister’s Office. The PMO had written to the Sports Ministry to look into the matter, which, in turn, directed the NADA to do so. Sanjita’s ‘A’ sample, taken out-of-competition in the United States on November 18 before the World Championships last year, tested positive for an anabolic steroid. The dope result (of A sample), however, came only on May 15 when she was put under provisional suspension. The ‘B’ sample request was made in June and the result was given to her on September 11. Sanjita has also requested the IWF to reveal the name of the weightlifter whose sample number is 1599176 and which was mentioned in one place in the letter sent to her informing her about her dope flunk. the number had (though mistakenly) appeared in my suspension order, I assume it is my right to know him/her. This will help me in convincing how the mistake occurred,” she said in the letter written to the IWF. PTI PDS PM PM
First-year students who valued and enjoyed their alone time seemed to display greater psychological health Solitary time can be useful for detaching oneself from societal pressures and getting back to one’s own values and interests, which in turn allows for better behavior regulation (with a greater sense of autonomy, choice, and self-concordance) The association between freely chosen motivation for solitude and psychological health is stronger for those who don’t feel they belong in college The findings held across two independent samples of first-year students–one at a private university in the US and one at a public university in Canada Parents play a role in shaping their children’s capacity to be alone by allowing children time for independent play. The study provides empirical evidence for the theory formulated by English pediatrician and psychoanalyst Donald Woods Winnicott in the 1950s. What do the researchers wish they had known as a green, first-year student?”I wish I had known to worry less,” says Nguyen. The transition to college can be difficult with the pressure to socialize and make new friends, she notes. However, it’s important to consider that alone time is also valuable.”At times we do want time to ourselves, to relax, so it is OK to take time for that as well,” says Nguyen.”Being alone does not make you a loner, which is a very easy stereotype to internalize when you first enter college–especially when you think that everyone around you is socializing when you are not. Solitude is a personal experience for everyone, so it is a time for you to take if you want, and just explore different ways to make it a meaningful and enjoyable experience for you.” Reviewed by James Ives, M.Psych. (Editor)Apr 10 2019Transitioning from high school to college can be stressful. Trying to fit in, making new friends, missing old ones and home, meeting professors’ and one’s own expectations–can all be daunting.The way that first-year students manage (or not) to navigate this change has long-term implications for their academic performance and ability to stick with their studies. Research has shown that one frequent pitfall during this transition period from high school to college is social isolation. Loneliness, of course, can have a serious detrimental effect on a student’s mental health, potentially leading to depression.But being alone isn’t necessarily bad, argues a team of researchers from the University of Rochester, Carleton University in Ottawa, Canada, and Ghent University in Belgium. They published their findings about the importance of me-time in the journal Motivation and Emotion.”Approaching solitude for its enjoyment and intrinsic values is linked to psychological health, especially for those who don’t feel as if they belong to their social groups,” says the study’s lead author, Thuy-vy Nguyen, who received her doctorate in psychology from the University of Rochester in 2018 and who undertook large part of the research for this study in Rochester.”These findings highlight the importance of cultivating the ability to enjoy and value solitary time as a meaningful experience, rather than trying to disregard it, or escape from it,” says Nguyen, who’ll be joining the psychology department at Durham University, England, this fall as an assistant professor.Loneliness versus alone timeWhat then marks the difference between useful and potentially detrimental solitude? The key is positive motivation, according to the researchers. A healthy, autonomous seeking of alone time is associated with greater self-esteem, a greater sense of feeling related to others, and feeling less lonely. Conversely, someone who wants to be alone because of negative social experiences will more likely experience the negative effects of solitude, such as isolation or social withdrawal. The reasons matter as they determine how we experience solitude and the benefits we can get from it, the study concludes.Nguyen is building on decades of research by her veteran Rochester mentors, Edward Deci and Richard Ryan, co-founders of self-determination theory (SDT). The theoretical framework of SDT fits nicely into the investigation of how individuals’ motivations for spending time alone contribute to well-being, the researchers note. Per definition, autonomous motivation for being alone refers to a person’s decision to spend time in solitude in a manner that is valuable and enjoyable for the person.Previous research had shown that spending too much time socializing during the first year of college–and as a result having little time for oneself–may be associated with poor adjustment.Related StoriesResearch sheds light on sun-induced DNA damage and repairWhy Mattresses Could be a Health Threat to Sleeping ChildrenPerinatal depression screenings may overlook women having suicidal ideationBut over the course of two studies, conducted with 147 first-year college students in the US (testing for self-esteem) and 223 in Canada (testing for loneliness and relatedness), the team was able to untangle the interaction between new students’ social life and their motivation for spending time alone as a predictor of their successful adjustment to college life.Nguyen says the interplay between solitary time and our social experiences has not been empirically studied before, at least not in this way.”In previous research, it has been framed in ways that those with more access to social connections tend to have a better time in solitude. But in our study, having a healthy motivation for solitude actually is associated with wellness for those who have less access to social connections,” says Nguyen.The findings in a nutshell: Source:https://www.rochester.edu/newscenter/college-freshmen-need-alone-time-373042/
The charity wants the Government to act on its ambition to halve childhood obesity rates by 2030 and introduce a 9 pm watershed for junk food adverts on TV and online, alongside other measures such as restricting promotional offers on unhealthy food and drinks.Professor Linda Bauld, Cancer Research UK’s prevention expert, commented: There isn’t a silver bullet to reduce obesity, but the huge fall in smoking over the years – partly thanks to advertising and environmental bans – shows that Government-led change works. It was needed to tackle sky-high smoking rates, and now the same is true for obesity.The world we live in doesn’t make it easy to be healthy and we need Government action to fix that, but people can also make changes themselves; small things like swapping junk food for healthier options and keeping active can all add up to help reduce cancer risk.” As smoking rates fall and obesity rates rise, we can clearly see the impact on a national health crisis when the Government puts policies in place – and when it puts its head in the sand.Our children could be a smoke-free generation, but we’ve hit a devastating record high for childhood obesity, and now we need urgent Government intervention to end the epidemic. They still have a chance to save lives.Scientists have so far identified that obesity causes 13 types of cancer but the mechanisms aren’t fully understood. So further research is needed to find out more about the ways extra body fat can lead to cancer.” Reviewed by James Ives, M.Psych. (Editor)Jul 3 2019New figures from Cancer Research UK show that people who are obese now outnumber people who smoke two to one in the UK, and excess weight causes more cases of certain cancers than smoking, as the charity urges Government action to tackle obesity.Almost a third of UK adults are obese and, while smoking is still the nation’s biggest preventable cause of cancer and carries a much higher risk of the disease than obesity, Cancer Research UK’s analysis revealed that being overweight or obese trumps smoking as the leading cause of four different types of cancer.Excess weight causes around 1,900 more cases of bowel cancer than smoking in the UK each year. The same worrying pattern is true of cancer in the kidneys (1,400 more cases caused by excess weight than by smoking each year in the UK), ovaries (460) and liver (180).Related StoriesLiving with advanced breast cancerResearch sheds light on sun-induced DNA damage and repairSpecial blood test may predict relapse risk for breast cancer patientsCancer Research UK launched a nationwide campaign this week to increase awareness of the link between obesity and cancer. Extra body fat sends out signals that can tell cells to divide more often and can cause damage that builds up over time and raises the risk of cancer.The campaign compares smoking and obesity to show how policy change can help people form healthier habits, not to compare tobacco with food.Michelle Mitchell, Cancer Research UK’s chief executive, said: Source:Cancer Research UK
Reviewed by Kate Anderton, B.Sc. (Editor)Jun 27 2019Insights into how a gene that increases the risk of Alzheimer’s disease disrupts brain cells have been revealed by scientists.Brain tissue from people with Alzheimer’s showed that a protein called clusterin builds up in vital parts of neurons that connect cells and may damage these links.Scientists say the findings shed light on the causes of the disease and will help to accelerate the search for a treatment.The study, led by Professor Tara Spires-Jones at the University of Edinburgh, focused on synapses – connections between brain cells that allow the flow of chemical and electrical signals. These signals are vital for forming memories and are key to brain health, experts say.Related StoriesResearchers discover gene linked to healthy aging in wormsNew therapy shows promise in preventing brain damage after traumatic brain injuryPosterior parietal cortex plays crucial role in making decisions, research showsResearchers showed that synapses in people who had died with Alzheimer’s contained clumps of clusterin, which could contribute to dementia symptoms. These synapses also contained clumps of amyloid beta, the damaging protein that is found in the brains of people with Alzheimer’s.People with a common risk gene, called apolipoprotein E4, had more clusterin and amyloid beta clumps in their synapses than people with Alzheimer’s without the risk gene.Those without dementia symptoms had even less of the damaging proteins in their synapses.The discovery was made using powerful technology that allowed the scientists to view detailed images of more than one million synapses. Individual synapses are around 5000 times smaller than the thickness of a sheet of paper.Synapse loss in Alzheimer’s disease was previously established, but the clumping of damaging proteins together in synapses was unknown until now because of difficulties in studying them due to their tiny size.Alzheimer’s disease is the most common form of dementia, affecting around 500,000 people in the UK. It can cause severe memory loss and there is no cure.Professor Spires-Jones, Programme Lead at the UK Dementia Research Institute at the University of Edinburgh, said: We have identified another player in the host of proteins that damage synapses in Alzheimer’s disease. Synapses are essential for thinking and memory, and preventing damage to them is a promising target to help prevent or reverse dementia symptoms. This work gives us a new target to work towards in our goal to develop effective treatments.” Source:University of EdinburghJournal reference:Spires-Jones, T. et al. (2019) Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers. Brain Communications. doi.org/10.1093/braincomms/fcz003.